MS for LC2019-09-10T10:02:15+02:00

Mass spectrometry for Liquid Chromatography

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Use Thermo Scientific liquid chromatography mass spectrometry (LC-MS) systems to identify, characterize and quantify unknown and known compounds within complex matrices, including drug metabolites, environmental toxins and food additives. Our systems enable you to streamline your workflow and obtain more information from every run, from high throughput sample screening to discovering trace levels of unknowns.

Triple Quadrupole LC-MS

Thermo Scientific Triple Quadrupole LC-MS/MS systems combine full scan capacity with the sensitivity of selected ion and reaction monitoring modes for targeted compound analysis.

Triple quadrupole LC-MS system product comparison

Different applications require different levels of system sensitivity, resolution, and speed. In this table, we compare different TSQ triple quadrupole systems in order to showcase which ones are most relevant to your laboratory’s needs.

TSQ Fortis™ Triple Quadrupole (MS) TSQ Quantis™ Triple Quadrupole (MS) TSQ Altis™ Triple Quadrupole (MS)
Sensitivity +++ ++++ ++++
Resolution ++ ++ +++
Scan Speed ++++ ++++ ++++
Applications across multiple matrices
Targeted quantitation in Proteomics
Peptide and protein quantitation (Biopharma)
Small molecule quantitation (Pharma, Clinical Research)
Small molecule mixture quantitation (Environmental Safety, Food Safety, Forensic Toxicology, Pharma)
Analysis and targeted quantitation of trace impurities (Impurity Quantitation)
Analysis and targeted quantitation of trace impurities (Impurity Quantitation)
Targeted quantitation in Omics (metabolomics, lipidomics)
Compatible separation technologies UltiMate, Vanquish, Multiplexing, Capillary LC, Other vendors UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC UltiMate, Vanquish, Other vendors, IC, Multiplexing, Capillary LC, NanoLC

Orbitrap LC-MS

Thermo Scientific Orbitrap mass spectrometers are designed for novel compound discovery in proteomics, biopharma, and metabolomics, using applications like isobaric tags and low level PTM analysis. These mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization and quantitation, and comprehensive sample analysis.

Orbitrap LC-MS Comparison Chart

Benefit from the high-resolution, accurate-mass (HRAM) performance advantages offered by our unique Orbitrap mass analyzers. Orbitrap systems connect to liquid chromatography equipment to enhance separation of unknown compounds and enable high-throughput workflows.

Orbitrap Fusion™ Tribrid™ MS Q Exactive™ Hybrid Quadrupole-Orbitrap™ MS
Max resolution (FWHM) @m/z 200 500k 140k (280k Enh R)
Mass accuracy, (internal) <1ppm <1 ppm
Mass range - 50 to 6,000 m/z
Scan rates 20Hz 12 Hz
Polarity switch < 1.1 sec <1 sec
PRM Yes
Multiplex (precursor/ scan) 10 10
MSn (n=10)

Single Quadrupole LC-MS

These economical high-performance MS systems have the capacity to keep up with even the fastest UHPLC applications. They are ideal for routine analysis and function in full-scan and selected ion monitoring (SIM) modes. Thermo Scientific Chromeleon software helps users to master MS with integrated tools and guides that make operating and controlling your LC-MS system easy and intuitive.

Single quadrupole mass spectrometer comparison chart

Gain more confidence and invest in your lab’s future via Thermo Scientific single quadrupole mass spectrometry (MS). MS provides sensitivity and selectivity for your analyses, giving you more insight into your samples and ability to resolve difficult separations, including co-eluting peaks, using differing mass-to-charge (m/z) ratios. Our single quadrupole MS systems set new standards for robustness and ease-of-use. They are built for every day, reliable routine operation with seamless integration into your HPLC or UHPLC system.

ISQ™ EM Single Quadrupole MS ISQ™ EC Single Quadrupole MS
Application Liquid Chromatography Ion Chromatography and Liquid Chromatography
Mass Range 10 – 2000 m/z 10 – 1250 m/z
Supported Modes Full scan / SIM Full scan / SIM
Mass Resolution Unit (≤ 1.0 Da) Unit (≤ 1.0 Da)
Mass Accuracy < ± 0.1 Da < ± 0.1 Da
Scan Rate, max Up to 20000 (Da/s) Up to 20000 (Da/s)
Stability < 0.1 Da over 48 h < 0.1 Da over 48 h
Type HESI and HESI/APCI HESI
Max Flow Rate 2mL/min 2mL/min
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